CLH Clinical Research

Course in CLH:
CLH 200Introduction to Translational Research (1) Active
Lecture—1 hour(s). Prerequisite(s): Consent of Instructor. One of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM/CTSC training programs. Introduction to the CRGG program and overview of major clinical research topics. Overview of basic clinical skills needed to accomplish CRGG mentored research project. (S/U grading only.) Effective: 2018 Summer Quarter.
CLH 201Strategies for Grant Writing (2) Active
Lecture—2 hour(s). Prerequisite(s): Consent of Instructor. Completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing. Application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM/CTSC training program. Practical skills and strategies to create successful grant proposals in NIH style/format. Generating ideas, identifying and accessing research resources, grant components, specific aims, background and significance, preliminary studies, budgets, and bios. Matriculation through UC system, and resubmissions. (Former course MDS 461CR.) (S/U grading only.) Effective: 2008 Summer Special Session.
CLH 202Introduction to Clinical Research (3) Active
Lecture—2 hour(s); Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, MRCTP program, Clinical Research Certificate or other SOM/CTSC training programs. Anatomy and physiology of conducting clinical epidemiologic research. Familiarity with three basic study designs: cross-sectional, case-control, and cohort. Discussion of principles of measurements in clinical epidemiological studies, basic methods for analyzing data, and ethical issues involved in conducting research. (Letter.) Effective: 2019 Winter Quarter.
CLH 203Methods in Clinical Research (3) Active
Lecture—4 hour(s); Discussion—1 hour(s); Independent Study—10 hour(s). Prerequisite(s): Consent of Instructor. Completed one of the following degrees: MD, DDS, DMD, OD, ND, DO, PharmD, DVM, PhD or DNS in nursing; application and acceptance into the Clinical Research Graduate Group, K30 program or other SOM traing programs. Overview of major approaches to clinical research, including health services research techniques, informatics, GCRC, and preclinical methodologies to enhance clinical projects. Overview of UCD clinical research support infrastructure. Methodologies applicable to clinical research and its multi-disciplinary perspective. (S/U grading only.) Effective: 2015 Spring Quarter.
CLH 204The Ethics of Research (1) Active
Lecture—1 hour(s). Prerequisite(s): Consent of Instructor. Priority given to those with acceptance into the Clinical Research Graduate Group, K12, T32 or other SOM/CTSC training program. Acquire information about ethical responsibilities; Explore major questions in ethics; Apply ethical principles, concepts and values; Gain an appreciation of the role of trust in scientific research. Recommend three quarters of CLH204. Must enroll in Fall to continue through Spring. May be repeated up to 3 Unit(s). (S/U grading only.) Effective: 2016 Fall Quarter.
CLH 207Team Science (1) Active
Lecture/Discussion—1 hour(s). Prerequisite(s): Participation in CTSC Research Education and Training Programs, or consent of instructor. Restricted to 25 students. Today’s scientific challenges necessitate cross-disciplinary engagement and high collaboration levels. This course offers guidance on how best to engage in team science to pursue complex questions, work effectively with team members, and produce high impact research that meets society’s needs. (S/U grading only.) Effective: 2015 Winter Quarter.
CLH 208Introduction to Grant Writing, I (2) Active
Lecture/Discussion—2 hour(s); Extensive Writing. First in a two-quarter series. Scholars are encouraged to enroll in both classes. The two-course sequence provides training in practical aspects of competitive grant writing. The focus is NIH, but information will apply to other funding agencies. (S/U grading only.) Effective: 2014 Fall Quarter.
CLH 209Introduction to Grant Writing, II (1) Active
Lecture/Discussion—1 hour(s). Prerequisite(s): CLH 208; Consent of Instructor. Restricted to students who have completed course 208. Second in a two-quarter series. Two-course sequence provides training in practical aspects of competitive grant writing. (S/U grading only.) Effective: 2016 Fall Quarter.
CLH 210YPrinciples and Methods of Comparative Effectiveness Research (4) Active
Web Virtual Lecture—4 hour(s); Discussion—2 hour(s); Project (Term Project)—6 hour(s); Web Electronic Discussion. Prerequisite(s): Consent of Instructor. Familiarity with research methodology, and a course in introductory statistics. Provides an introduction to Comparative Effectiveness Research (CER) and methods for conducting CER. (S/U grading only.) Effective: 2015 Winter Quarter.
CLH 211Critical Assessment of the Biomedical Literature (1) Active
Lecture/Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Exposes students to topical issues and controversies in the design of interdisciplinary translational research, with an emphasis on critical assessment of the biomedical and health sciences literature. The course extends students’ knowledge of study design through practical application. May be repeated up to 3 Unit(s). (S/U grading only.) Effective: 2016 Fall Quarter.
CLH 212Introduction to Stem Cell Biology (3) Active
Lecture/Discussion—3 hour(s). Open to graduate students with a fundamental knowledge of cell biology. Introduction to Stem Cell Biology. Each week will focus on different aspects of stem cells, including general concepts, stem cells in lower organisms, embryonic stem cells and cellular reprogramming. (Letter.) Effective: 2016 Spring Quarter.
CLH 214ABiodesign I (2) Active
Lecture—2 hour(s). Prerequisite(s): Consent of Instructor. Prior approval by instructor required; student must commit to taking both courses; Biodesign I and Biodesign II. Focuses on the principles of needs identification and invention of biomedical technologies. Two part course provides a basic understanding of the elements of the innovation process and how to translate these principles into biomedical device design. (Letter.) Effective: 2016 Fall Quarter.
CLH 214BBiodesign II (2) Active
Lecture—2 hour(s). Prerequisite(s): CLH 214A; Consent of Instructor. Prior approval by instructor required; student must commit to taking both courses; Biodesign I and Biodesign II. Focuses on the implementation of biomedical technologies and translational process. Two part course provides a basic understanding of the elements of the innovation process and how to translate these principles into biomedical device design. (Letter.) Effective: 2017 Winter Quarter.
CLH 220Basics of Stem and Progenitor Cells (1) Active
Lecture—1 hour(s). Prerequisite(s): MCP 200L; MCP 200; Consent of Intructor; Graduate standing. This is a lecture course designed for graduate students who have experience in cell culture techniques. It is designed to give a broad overview of the field and current cells of interest to the greater research community. (S/U grading only.) Effective: 2007 Spring Quarter.
CLH 222Ethical Issues in Stem Cell Biology (1) Active
Lecture/Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Graduate standing. Critical presentation and analysis of recent articles in stem cell biology and small group discussions of the ethical issues surrounding this area of research. (S/U grading only.) Effective: 2007 Winter Quarter.
CLH 230Congestive Heart Failure, Mechanism of Disease (3) Active
Lecture/Discussion—2 hour(s); Project (Term Project). Prerequisite(s): Consent of Instructor. Graduate standing. Underlying mechanisms of cardiomyopathy and heart failure. Presentation of fundamental knowledge of and recent basic research on heart failure. Student team projects: investigation and presentation of a research topic and bench research project to advance research in the same area. (Letter.) Effective: 2008 Summer Session 1.
CLH 231Current Techniques in Clinical Research (2) Active
Lecture—1 hour(s); Clinical Activity—3 hour(s). Prerequisite(s): CLH 250; and Consent of Instructor. Graduate standing. Current techniques used in clinical research such as electrophysiology, cardiovascular surgery, cardiac catheterization and echocardiography, team science, and patient management. Lectures are presented by experts on each technique, with an emphasis on use in translational research. (S/U grading only.) Effective: 2006 Fall Quarter.
CLH 233Molecular Mechanisms of Disease: Cancer (3) Active
Lecture/Discussion—2 hour(s); Project (Term Project)—3 hour(s). Prerequisite(s): Consent of Instructor. Restricted to students pursuing the designated emphasis in Translational Research; graduate standing. Cutting edge of research on underlying mechanisms of cancer development, progression and prevention—clinical trials/drug development, signaling pathways and molecular mechanisms of cancer development, recent basic research on cancer stem cells, genetics and epigenetic events and animal models used. (Letter.) Effective: 2013 Fall Quarter.
CLH 240Predoctoral Clinical Research Training Program Research Integration (1) Active
Seminar—0.5 hour(s); Discussion—0.5 hour(s). Prerequisite(s): Consent of Instructor. Enrollment in the Predoctoral Clinical Research Training Program in the CTSC, School of Medicine. Alternating sessions: journal club, seminar/discussion, and research integration sessions. May be repeated up to 3 Time(s). (S/U grading only.) Effective: 2007 Fall Quarter.
CLH 244Introduction to Medical Statistics (4) Active
Lecture—4 hour(s). Introduction to statistical methods and software in clinical, laboratory and population medicine. Graphical and tabular presentation of data, probability, binomial, Poisson, normal, t-, F-, and Chi-square distributions, elementary nonparametric methods, simple linear regression and correlation, life tables. Only one unit of credit for students who have completed STA 100 or MPM 402. (Same course as SPH 244.) (Letter.) Effective: 2017 Winter Quarter.
CLH 245Biostatistics for Biomedical Science (4) Active
Lecture—4 hour(s). Prerequisite(s): CLH 244 or SPH 244; Consent of Instructor. Or equivalent. Analysis of data and design of experiments for laboratory data. (Same course as SPH 245.) (Letter.) Effective: 2015 Spring Quarter.
CLH 246Biostatistics for Clinical Research (4) Active
Lecture—4 hour(s). Prerequisite(s): CLH 245 or SPH 245. Emphasizes critical biostatistics for clinical research and targets biomedical audience. Students will develop understanding for basic planning and analysis of clinical studies and learn to develop collaborations with biostatisticians. May be repeated for credit. (Same course as SPH 246.) (Letter.) Effective: 2015 Winter Quarter.
CLH 247Statistical Analysis for Laboratory Data (4) Active
Lecture—4 hour(s). Prerequisite(s): CLH 245 or SPH 245. Statistical methods for experimental design and analysis of laboratory data including gene expression arrays, RNA-Seq, and mass spec. (Same course as SPH 247.) (Letter.) Effective: 2015 Spring Quarter.
CLH 250Integrating Medicine Into Basic Science (6) Active
Lecture—3.7 hour(s); Discussion—6 hour(s); Seminar—2.5 hour(s); Clinical Activity—8 hour(s). Graduate standing; acceptance into HHMI Integrating Medicine into Basic Science program. Four-week summer institute consisting of didactic lectures, reading assignments, group discussions, and clinical rotations to acculturate students to the human medical environment; integrate medical principles, physiology and pathophysiology into basic research; introduce high-impact clinical studies related to medicine and health. (S/U grading only.) Effective: 2006 Fall Quarter.
CLH 290AHot Topics in Clinical Research (1) Active
Seminar—1 hour(s). Prerequisite(s): Graduate standing or consent of instructor. Seminars presented by guest lecturers on subjects of their own research activities May be repeated for credit. (S/U grading only.) Effective: 2006 Fall Quarter.
CLH 290BHot Topics in Stem Cell Biology (1) Active
Seminar—1 hour(s). Prerequisite(s): Consent of Instructor. Graduate standing. Seminars presented by guest lecturers on subjects of their own research (S/U grading only.) Effective: 2006 Fall Quarter.
CLH 290CLiterature in Stem Cell Biology (1) Active
Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Graduate standing. Critical presentation and analysis of recent journal articles in stem cell biology by students. May be repeated for credit. (S/U grading only.) Effective: 2006 Fall Quarter.
CLH 290DLiterature in Translational Research (1) Active
Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Graduate standing. Critical presentation and analysis of recent journal articles in translational research by students. May be repeated for credit. (S/U grading only.) Effective: 2009 Fall Quarter.
CLH 298Group Study in Clinical Research (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Restricted to students enrolled in the Mentored Clinical Research Training Program. Special topics in Clinical Research appropriate for group study at the graduate level. May be repeated for credit. (S/U grading only.) Effective: 2006 Winter Quarter.
CLH 299Clinical Research (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Restricted to students enrolled in the Mentored Clinical Research Training Program. Independent research and special topics in clinical research appropriate for graduate level. May be repeated for credit. (S/U grading only.) Effective: 2006 Fall Quarter.