Biomedical Engineering; Engineering

(College of Engineering)

Alyssa Panitch, Ph.D., Chairperson of the Department

Anthony Passerini, Ph.D., Vice Chair for Education

Department Office. 2303 Genome and Biomedical Sciences Facility; 530-752-1033; https://bme.ucdavis.edu

Faculty. https://bme.ucdavis.edu/people/departmental -faculty/

(College of Engineering)

Alyssa Panitch, Ph.D., Chairperson of the Department

Anthony Passerini, Ph.D., Vice Chair for Education

Department Office. 2303 Genome and Biomedical Sciences Facility; 530-752-1033; https://bme.ucdavis.edu

Faculty. https://bme.ucdavis.edu/people/departmental -faculty/

The Biomedical Engineering Undergraduate Major

The Biomedical Engineering program is accredited by the Engineering Accreditation Commission of ABET; see http://www.abet.orghttp://www.abet.org.

Biomedical engineering is an interdisciplinary area of study that integrates knowledge of engineering principles with the biomedical sciences. It is a very diverse field, with biomedical engineers working in areas ranging from medical imaging to regenerative medicine. Some major contributions of biomedical engineering include the left ventricular assist device (LVAD), artificial joints, hemodialysis, bioengineered skin, coronary stents, computed tomography (CT), and flexible endoscopes. Students who choose biomedical engineering are interested in contributing to human health but do not routinely interact directly with patients, as do physicians. Due to the need to complete additional coursework beyond BME degree requirements, this major is not a primary route for pre-medical studies.

The mission of the BS degree program of the Department of Biomedical Engineering is to combine exceptional teaching with state-of-the-art research for the advancement of technologies and computational techniques that meet medical and societal challenges.

The educational objectives of our program are that our graduates be successfully engaged in their chosen career through engineering practice, academic or clinical research, healthcare, education, service, or related activities, or through pursuit of graduate or professional degrees; and contribute effectively to society through responsible professional practice, fostering of cross-disciplinary collaboration, generation of innovative solutions to problems, and continuous pursuit of knowledge for personal and technological advancement.

The biomedical engineering curriculum has been designed to provide a solid foundation in mathematics, life and physical sciences, and engineering, and to provide sufficient flexibility in the upper division requirements to encourage students to explore specializations within the field. Our instructional program is designed to impart knowledge of contemporary issues at the forefront of biomedical engineering research. Employment opportunities exist in industry, hospitals, academic research and teaching institutes, national laboratories, or government regulatory agencies. The major also provides excellent grounding in the skills necessary for professional or graduate-level studies in biological and health sciences. Exclusive of General Education units, the minimum number of units required for the Biomedical Engineering degree is 157.

For information about graduate degree options, see Biomedical Engineering (Graduate Group).

Areas of Specialization

As Biomedical engineering is defined so broadly, specializing in a subfield of engineering can provide more in-depth expertise in a focus area. Through the judicious selection of upper division engineering and science electives, students can create this depth in one of our suggested areas of specialization or in an area of the student's choosing. One of the strengths of the UC Davis program is the flexibility to design one's own emphasis of study. These specializations are neither required nor degree-notated.

Biomechanics. This is a broad subfield that includes orthopedic/rehabilitation engineering (including the design of wheelchairs and prosthetics) as well as the study of mechanical forces produced by biological systems. Biomechanics allows a better understanding of the fluid dynamics of blood flow and the forces acting on tissue in the artery to allow the design of better cardiovascular interventions. This field involves more intensive study of mechanics, dynamics and thermodynamics.

Cellular and Tissue. This focus area applies biomedical engineering principles to control behavior at the gene, protein, cell, and tissue level. Scientists in this area can work in diverse areas including cellular therapies, protein production, gene therapy, tissue engineering and regeneration, and biomaterials development. This field can require study in biomedical transport, natural or synthetic biomaterials, pharmacokinetics and pharmacodynamics. It draws heavily from knowledge in the chemical and biological sciences.

Imaging. The visualization of anatomical structure, physiological processes, metabolic activity and molecular expression in living tissues is important to accomplish goals that include the diagnosis of disease, the development of new therapeutics, the evaluation of the response to therapeutics, and the guidance of interventional procedures. Our program has a particular strength in molecular imaging, in which molecular-scale events are detected within living systems. An imaging bioengineer can work in areas ranging from developing instruments for imaging, to creating algorithms for three-dimensional reconstruction of imaging data, to generating new contrast agents for enhancing image quality. Depending upon the area of interest, this field can require further study in electronics signal processing, chemistry or computer programming.

Medical Devices. This is a diverse area that can include the development of instruments, apparatuses, machines, implants, or in-vitro reagents intended for use in the diagnosis, treatment or prevention of disease. Biomedical engineers have begun to combine technologies including pharmaceuticals, electronics and mechanical devices in the development of combination medical treatments.

Systems & Synthetic Biology. In this area, concepts, principles and techniques from engineering are applied to understand and build biological processes and systems at a fundamental level. Engineers describe biochemical, genetic and mechanical processes mathematically and integrate this information into models of natural and synthetic systems. These models are studied analytically, computationally and statistically to uncover design principles of natural systems and to guide development of methods capable of redirecting normal expression for biotechnological purposes or correcting pathological expression for therapeutic purposes.

Pre-Medical Student. Engineering is playing an increasing role in the practice of medicine, and students interested in medicine can focus on the intersection of engineering and medicine. To meet admission requirements for medical school, students must complete extra course work. These courses are in addition to the listed Department of Biomedical Engineering curricular requirements.

The Graduate Program in Biomedical Engineering. Doctoral and master's degrees in Biomedical Engineering are offered through the interdisciplinary Graduate Group in Biomedical Engineering. Please see http://www.bme.ucdavis.edu and Biomedical Engineering (Graduate Group).

Lower Division Required Courses
Units: 81
Students are encouraged to adhere carefully to all prerequisite requirements. The instructor is authorized to drop students from a course for which stated prerequisites have not been completed.
 
MAT 021A
Calculus (Active)
4
or
MAT 021AH
Honors Calculus (Active)
4
and
MAT 021B
Calculus (Active)
4
or
MAT 021BH
Honors Calculus (Active)
4
and
MAT 021C
Calculus (Active)
4
or
MAT 021CH
Honors Calculus (Active)
4
and
MAT 021D
Vector Analysis (Active)
4
MAT 022A
Linear Algebra (Active)
3
MAT 022B
Differential Equations (Active)
3
PHY 009A
Classical Physics (Active)
5
or
PHY 009HA
Honors Physics (Active)
5
PHY 009B
Classical Physics (Active)
5
PHY 009C
Classical Physics (Active)
5
CHE 002A
General Chemistry (Active)
5
or
CHE 002AH
Honors General Chemistry (Active)
5
and
CHE 002B
General Chemistry (Active)
5
or
CHE 002BH
Honors General Chemistry (Active)
5
and
CHE 002C
General Chemistry (Active)
5
or
CHE 002CH
Honors General Chemistry (Active)
5
CHE 008A
Organic Chemistry: Brief Course (Active)
2
or
CHE 118A
Organic Chemistry for Health and Life Sciences (Active)
4
and
CHE 008B
Organic Chemistry: Brief Course (Active)
4
or
CHE 118B
Organic Chemistry for Health and Life Sciences (Active)
4
ENG 006
Engineering Problem Solving (Active)
4
ENG 017
Circuits I (Active)
4
BIS 002A
Introduction to Biology: Essentials of Life on Earth (Active)
5
BIM 001
Introduction to Biomedical Engineering (Active)
2
BIM 020
Fundamentals of Bioengineering (Active)
4
Choose one; a grade of C- or better is required:
4
UWP 001
Introduction to Academic Literacies (Active)
4
UWP 001Y
Introduction to Academic Literacies (Active)
4
UWP 001V
Introduction to Academic Literacies: Online (Active)
4
ENL 003
Introduction to Literature (Active)
4
COM 001
Major Works of the Ancient World (Active)
4
COM 002
Major Works of the Medieval and Early Modern World (Active)
4
COM 003
Major Works of the Modern World (Active)
4
COM 004
Major Works of the Contemporary World (Active)
4
NAS 005
Introduction to Native American Literature (Active)
4
Upper Division Required Courses
Units: 76-80
ENG 100
Electronic Circuits and Systems (Active)
3
or
EEC 100
Circuits II (Active)
5
ENG 105
Thermodynamics (Active)
4
ENG 190
Professional Responsibilities of Engineers (Active)
3
BIM 116
Physiology for Biomedical Engineers (Active)
5
or
NPB 101
Systemic Physiology (Active)
5
BIM 105
Probability and Statistics for Biomedical Engineers (Active)
4
BIM 106
Biotransport Phenomena (Active)
4
BIM 108
Biomedical Signals and Control (Active)
4
BIM 109
Biomaterials (Active)
4
BIM 110A
Biomedical Engineering Senior Design Experience (Active)
3
BIM 110B
Biomedical Engineering Senior Design Experience (Active)
3
BIM 110B
Biomedical Engineering Senior Design Experience (Active)
3
BIM 111
Biomedical Instrumentation Laboratory (Active)
6
Science and Engineering electives are to be selected in consultation with a staff or faculty advisor.
 
Science Electives
7
To be chosen according to specialization.
 
BIS 002B
Introduction to Biology: Principles of Ecology and Evolution (Active)
5
BIS 002C
Introduction to Biology: Biodiversity and the Tree of Life (Active)
5
ECS 030
Programming and Problem Solving (Discontinued)
4
ECS 040
Software Development and Object-Oriented Programming (Discontinued)
4
PHY 009D
Modern Physics (Active)
4
BIM 102
Cellular Dynamics (Active)
4
BIM 161A
Biomolecular Engineering (Active)
4
BIM 161L
Biomolecular Engineering Laboratory (Active)
3
BIM 161S
Biomolecular Engineering: Brief Course (Active)
1
CHE 118C
Organic Chemistry for Health and Life Sciences (Active)
4
or
Any graded upper division course in the Biological Sciences, Chemistry or Physics that is designated as Science and Engineering topical breadth.
 
With the approval of the Biomedical Engineering Undergraduate Committee; four units:
4
BIM 192
Internship in Biomedical Engineering (Active)
1-12
or
BIM 199
Special Study for Advanced Undergraduates (Active)
1-5
Engineering Electives
24
Any graded upper division Biomedical Engineering course; except:
 
BIM 102
Cellular Dynamics (Active)
4
BIM 161A
Biomolecular Engineering (Active)
4
BIM 161L
Biomolecular Engineering Laboratory (Active)
3
BIM 161S
Biomolecular Engineering: Brief Course (Active)
1
With the approval of the Biomedical Engineering Undergraduate Committee; four units:
4
BIM 192
Internship in Biomedical Engineering (Active)
1-12
or
BIM 199
Special Study for Advanced Undergraduates (Active)
1-5
No more than four units allowed from lower division coursework.
 
ENG 004
Engineering Graphics in Design (Active)
3
ENG 035
Statics (Active)
4
ENG 045
Properties of Materials (Active)
4
or
ENG 045Y
Properties of Materials (Active)
4
ENG 102
Dynamics (Active)
4
ENG 103
Fluid Mechanics (Active)
4
ENG 104
Mechanics of Materials (Active)
4
ENG 104L
Mechanics of Materials Laboratory (Active)
1
ENG 106
Engineering Economics (Active)
3
EEC 110A
Electronic Circuits I (Active)
4
EEC 110B
Electronic Circuits II (Active)
4
EEC 118
Digital Integrated Circuits (Active)
4
EEC 130A
Electromagnetics I (Active)
4
EEC 130B
Introductory Electromagnetics II (Active)
4
EEC 140A
Principles of Device Physics I (Active)
4
EEC 140B
Principles of Device Physics II (Active)
4
EEC 150A
Introduction to Signals and Systems I (Active)
4
EEC 150B
Introduction to Signals and Systems II (Active)
4
EEC 157A
Control Systems (Active)
4
EEC 157B
Control Systems (Active)
4
EEC 160
Signal Analysis and Communications (Active)
4
EBS 128
Biomechanics and Ergonomics (Active)
4
EBS 130
Modeling of Dynamic Processes in Biological Systems (Active)
4
EBS 165
Bioinstrumentation and Control (Active)
4
EBS 175
Rheology of Biological Materials (Active)
3
ECH 141
Fluid Mechanics for Biochemical and Chemical Engineers (Active)
4
ECH 144
Rheology and Polymer Processing (Active)
3
ECH 145A
Chemical Engineering Thermodynamics Laboratory (Active)
3
ECH 145B
Chemical Engineering Transport Lab (Active)
3
ECH 155
Chemical Engineering Kinetics and Reactor Design Laboratory (Active)
4
ECH 160
Fundamentals of Biomanufacturing (Active)
3
ECH 161A
Biochemical Engineering Fundamentals (Active)
4
ECH 161B
Bioseparations (Active)
4
ECH 161L
Bioprocess Engineering Laboratory (Active)
4
ECH 170
Introduction to Colloid and Surface Phenomena (Active)
3
ECS 124
Theory and Practice of Bioinformatics (Active)
4
EMS 147
Principles of Polymer Materials Science (Active)
3
EMS 160
Thermodynamics of Materials (Active)
4
EMS 162
Structure and Characterization of Engineering Materials (Active)
4
EMS 162L
Structure and Characterization of Materials Laboratory (Active)
2
EMS 164
Kinetics of Materials (Active)
4
EMS 172
Smart Materials (Active)
4
EMS 172L
Electronic, Optical and Magnetic Properties Laboratory (Active)
2
EMS 174
Mechanical Behavior of Materials (Active)
4
EMS 174L
Mechanical Behavior Laboratory (Active)
2
EMS 180
Materials in Engineering Design (Active)
4
EMS 181
Materials Processing (Active)
4
EMS 182
Failure Analysis (Active)
4
EME 050
Manufacturing Processes (Active)
4
EME 150A
Mechanical Design (Active)
4
EME 150B
Mechanical Design (Active)
4
EME 151
Statistical Methods in Design and Manufacturing (Active)
4
EME 152
Computer-Aided Mechanism Design (Active)
4
EME 154
Mechatronics (Active)
4
EME 165
Heat Transfer (Active)
4
EME 171
Analysis, Simulation and Design of Mechatronic Systems (Active)
4
EME 172
Automatic Control of Engineering Systems (Active)
4
Upper Division Composition Requirement
0-4
Choose one; grade of C- or better is required:
 
UWP 101
Advanced Composition (Active)
4
UWP 102B
Writing in the Disciplines: Biology (Active)
4
UWP 102E
Writing in the Disciplines: Engineering (Active)
4
UWP 104A
Writing in the Professions: Business Writing (Active)
4
UWP 104E
Writing in the Professions: Science (Active)
4
UWP 104F
Writing in the Professions: Health (Active)
4
UWP 104I
Writing in the Professions: Internships (Active)
4
UWP 104T
Writing in the Professions: Technical Writing (Active)
4
Passing the Upper Division Composition Exam offered by the College of Letters & Science.
 
Additional upper division elective policies:
 
Two units from Chemistry 118A may be applied towards Science electives if 118A is also used to satisfy lower division subject credit. Two units from Electrical and Computer Engineering 100 may be applied towards Engineering electives if Electrical and Computer Engineering 100 is taken to satisfy upper division subject credit.
 
Total: 157-161

(College of Engineering)

Alyssa Panitch, Ph.D., Chairperson of the Department

Department Office. 2303 Genome and Biomedical Sciences Facility 530-752-1033; https://bme.ucdavis.edu

The minor in Biomedical Engineering is restricted to enrolled College of Engineering students. The intent is to build upon their existing core strengths and add expertise in biomedical applications. This additional training would make students more attractive to employers in the medical device industry, and would also position students for graduate training in health related applications of engineering. The minor requires two life sciences courses not typically required for engineering students, one at the cellular level (Biomedical Engineering 102) and the other at the physiological level (Neurobiology, Physiology, and Behavior 101 or Biomedical Engineering 116). The remaining 12 units are to be selected in consultation with an advisor from the list of upper division Biomedical Engineering courses. Students will be advised to select additional courses to complement their existing curricula. Examples of relevant coursework for different majors are provided as a reference. These listings classify the upper division Biomedical Engineering courses into categories and provide a suggested subset of coursework for the majors most likely to have students interested in health-related applications.

Minor Requirements

All courses must be taken for a letter grade. A grade of C- or better is required for all courses used to satisfy minor requirements with an overall GPA of 2.000 or better in courses required for the minor. No more than one course can be counted towards both the student's major and the minor.

Minor Advisors. Rosalind Christian, Anthony Passerini

Biomedical Engineering
Units: 21
NPB 101
Systemic Physiology (Active)
5
or
BIM 116
Physiology for Biomedical Engineers (Active)
5
BIM 102
Cellular Dynamics (Active)
4
Electives
12
Electives to be chosen in consultation with the Biomedical Engineering Departmental Advisor.
 
BIM 117
Modeling Strategies for Biomedical Engineering (Active)
4
BIM 141
Cell and Tissue Mechanics (Active)
4
BIM 142
Principles and Practices of Biomedical Imaging (Active)
4
BIM 143
Biomolecular Systems Engineering: Synthetic Biology (Active)
4
BIM 143L
Synthetic Biology Laboratory (Active)
2
BIM 144
Fundamentals of Biophotonics and Bioimaging (Active)
4
BIM 152
Molecular Control of Biosystems (Active)
4
BIM 161A
Biomolecular Engineering (Active)
4
BIM 162
Introduction to the Biophysics of Molecules and Cells (Active)
4
BIM 163
Bioelectricity, Biomechanics, and Signaling Systems (Active)
4
BIM 167
Biomedical Fluid Mechanics (Active)
4
BIM 171
Clinical Applications for Biomedical Device Design (Active)
4
BIM 173
Cell and Tissue Engineering (Active)
4
BIM 189A
Topics in Biomedical Engineering; Cellular and Molecular Engineering (Active)
1-5
BIM 189B
Topics in Biomedical Engineering; Biomedical Imaging (Active)
1-5
BIM 189C
Topics in Biomedical Engineering; Biomedical Engineering (Active)
1-5
Total: 21
Courses in BIM:
BIM 001Introduction to Biomedical Engineering (2) Active
Lecture—1 hour(s); Laboratory—3 hour(s). Pass One open to freshmen. Introduction to the field of biomedical engineering with emphasis on design, careers, and specializations, including (1) medical devices (2) cellular & tissue engineering, (3) biomechanics, (4) systems & synthetic biology, and (5) biomedical imaging. (Letter.) GE credit: SE. Effective: 2016 Fall Quarter.
BIM 020Fundamentals of Bioengineering (4) Review all entries Historical
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): CHE 002B C- or better; MAT 021D C- or better; PHY 009B. Basic principles of mass, energy and momentum conservation equations applied to solve problems in the biological and medical sciences. Only two units of credit to students who have previously taken Chemical Engineering 51, Engineering 105. (Letter.) GE credit: QL, SE, VL. Effective: 2013 Fall Quarter.
BIM 020Fundamentals of Bioengineering (4) Review all entries Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): CHE 002B C- or better or CHE 002BH C- or better; MAT 021D C- or better; PHY 009B. Basic principles of mass, energy and momentum conservation equations applied to solve problems in the biological and medical sciences. Only two units of credit to students who have previously taken ECH 051, ENG 105. (Letter.) GE credit: QL, SE, VL. Effective: 2018 Fall Quarter.
BIM 088VIntroduction to Research (2) Active
Web Virtual Lecture—2 hour(s). Introduction to types of research, including the basics of joint research with a faculty mentor. Self-assessments to identify areas of interest, priorities, and fit. Literature search and library skills used in early stages of research. Research safety, integrity, and intellectual property. (Letter.) Effective: 2018 Winter Quarter.
BIM 089ATopics in Biomedical Engineering (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Restricted to lower division students. Topics in Biomedical Engineering. (A) Cellular and Molecular Engineering. May be repeated for credit when topic differs. (Letter.) GE credit: SE. Effective: 2012 Spring Quarter.
BIM 089BTopics in Biomedical Engineering (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Restricted to lower division students. Topics in Biomedical Engineering. (B) Biomedical Imaging. May be repeated for credit when topic differs. (Letter.) GE credit: SE. Effective: 2012 Spring Quarter.
BIM 089CTopics in Biomedical Engineering (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Restricted to lower division students. Topics in Biomedical Engineering. (C) Biomedical Engineering. May be repeated for credit when topic differs. (Letter.) GE credit: SE. Effective: 2012 Spring Quarter.
BIM 099Special Study for Undergraduates (1-5) Active
Variable. May be repeated for credit. (P/NP grading only.) GE credit: SE. Effective: 2003 Winter Quarter.
BIM 102Cellular Dynamics (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIS 002A; CHE 008B or CHE 118B. Open to College of Engineering students only. Fundamental cell biology for bioengineers. Emphasis on physical concepts underlying cellular processes including protein trafficking, cell motility, cell division and cell adhesion. Current topics including cell biology of cancer and stem cells will be discussed. Only two units of credit for students who have completed BIS 104. (Letter.) GE credit: SE. Effective: 2017 Spring Quarter.
BIM 105Probability and Statistics for Biomedical Engineers (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): MAT 021D C- or better; ENG 006 (can be concurrent). Concepts of probability, random variables and processes, and statistical analysis with applications to engineering problems in biomedical sciences. Includes discrete and continuous random variables, probability distributions and models, hypothesis testing, statistical inference and Matlab applications. Emphasis on BME applications. (Letter.) GE credit: QL, SE, VL. Effective: 2013 Fall Quarter.
BIM 106Biotransport Phenomena (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIM 020 C- or better; (BIM 116 or NPB 101); PHY 009B; MAT 022B. Open to Biomedical Engineering majors only. Principles of momentum and mass transfer with applications to biomedical systems; emphasis on basic fluid transport related to blood flow, mass transfer across cell membranes, and the design and analysis of artificial human organs. (Letter.) GE credit: QL, SE, SL, VL. Effective: 2015 Winter Quarter.
BIM 107Mathematical Methods for Biological Systems (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): ENG 006 C- or better; BIM 020; MAT 022B. Restricted to Biomedical Engineering majors only. Mathematical and computational modeling to solve biomedical problems. Topics include stochastic processes and Monte Carlo simulations, and partial differential equations. Introduced to numerical techniques in MATLAB. (Letter.) GE credit: QL, SE, VL. Effective: 2013 Fall Quarter.
BIM 108Biomedical Signals and Control (4) Active
Lecture—4 hour(s). Prerequisite(s): MAT 022B C- or better; ENG 006; ENG 017. Restricted to Biomedical Engineering majors only. Systems and control theory applied to biomedical engineering problems. Time-domain and frequency-domain analyses of signals and systems, convolution, Laplace and Fourier transforms, transfer function, dynamic behavior of first and second order processes, and design of control systems for biomedical applications. No credit for students who have taken EEC 150A; two units of credit for students who have taken EME 171. (Letter.) GE credit: QL, SE. Effective: 2012 Fall Quarter.
BIM 109Biomaterials (4) Review all entries Historical
Lecture—4 hour(s). Prerequisite(s): BIM 106; BIS 002A; CHE 002C. Restricted to upper-division Engineering majors. Introduce important concepts for design, selection and application of biomaterials. Given the interdisciplinary nature of the subject, principles of polymer science, surface science, materials science and biology will be integrated into the course. (Letter.) GE credit: SE, SL, VL. Effective: 2013 Fall Quarter.
BIM 109Biomaterials (4) Review all entries Active
Lecture—4 hour(s). Prerequisite(s): BIS 002A; CHE 002C or CHE 002CH; BIM 106. Restricted to upper-division Engineering majors. Introduce important concepts for design, selection and application of biomaterials. Given the interdisciplinary nature of the subject, principles of polymer science, surface science, materials science and biology will be integrated into the course. (Letter.) GE credit: SE, SL, VL. Effective: 2018 Fall Quarter.
BIM 110ABiomedical Engineering Senior Design Experience (3) Active
Lecture/Discussion—1 hour(s); Project (Term Project)—6 hour(s). Prerequisite(s): BIM 110L (can be concurrent); BIM 111 (can be concurrent). Restricted to senior Biomedical Engineering majors (or by consent of instructor). Application of bioengineering theory and experimental analysis to a design project culminating in the design of a unique solution to a problem. Design may be geared towards current applications in biotechnology or medical technology. Continues in course 110B. (Letter.) GE credit: OL, SE, SL, VL. Effective: 2017 Spring Quarter.
BIM 110BBiomedical Engineering Senior Design Experience (3) Active
Lecture/Discussion—1 hour(s); Project (Term Project)—6 hour(s). Prerequisite(s): BIM 110A. Application of bioengineering theory and experimental analysis to a design project culminating in the design of a unique solution to a problem. Design may be geared towards current applications in biotechnology or medical technology. (Letter.) GE credit: OL, SE, SL, VL. Effective: 2014 Spring Quarter.
BIM 110LBiomedical Engineering Senior Design Lab (2) Review all entries Historical
Laboratory—3 hour(s); Discussion/Laboratory—2 hour(s). Prerequisite(s): BIM 105; BIM 108; BIM 109. Restricted to Biomedical Engineering majors. Manufacturing processes, safety, computer-aided design techniques applied to fabrication of biomedical devices. Application of engineering principles & design theory to build a functional prototype to solve a biomedical problem. Continues in 110AB. (Letter.) GE credit: SE. Effective: 2017 Fall Quarter.
BIM 110LBiomedical Engineering Senior Design Lab (2) Review all entries Active
Laboratory—3 hour(s); Discussion/Laboratory—2 hour(s). Prerequisite(s): BIM 105; BIM 106; BIM 108; BIM 109; BIM 116 or NPB 101. Restricted to Biomedical Engineering majors. Manufacturing processes, safety, computer-aided design techniques applied to fabrication of biomedical devices. Application of engineering principles & design theory to build a functional prototype to solve a biomedical problem. Continues in 110AB. (Letter.) GE credit: SE. Effective: 2019 Winter Quarter.
BIM 111Biomedical Instrumentation Laboratory (6) Active
Lecture—4 hour(s); Discussion/Laboratory—4 hour(s). Prerequisite(s): BIM 105; BIM 108; (ENG 100 or EEC 100); (BIM 116 or NPB 101). Open to Biomedical Engineering majors only. Basic biomedical signals and sensors. Topics include analog and digital records using electronic, hydrodynamic, and optical sensors, and measurements made at cellular, tissue and whole organism level. (Letter.) GE credit: SE. Effective: 2015 Fall Quarter.
BIM 116Physiology for Biomedical Engineers (5) Active
Lecture—2 hour(s); Discussion—3 hour(s). Prerequisite(s): BIS 002A C- or better; PHY 009C; MAT 022B recommended. Basic human physiology for the nervous, musculoskeletal, cardiovascular, respiratory, gastrointestinal, renal, and endocrine systems. Emphasis on small group design projects and presentations in interdisciplinary topics relating biomedical engineering to medical diagnostic and therapeutic applications. (Letter.) GE credit: OL, SE, SL, VL, WE. Effective: 2013 Fall Quarter.
BIM 117Modeling Strategies for Biomedical Engineering (4) Active
Lecture—2 hour(s); Lecture/Discussion—2 hour(s). Prerequisite(s): BIS 002A C- or better; MAT 022A C- or better. Restricted to upper division standing. Non-simulation strategies for modeling biomedical engineering systems, including natural and synthetic systems at the cell and molecular level. Formulating and testing hypotheses by translating real-world problems into appropriate mathematical models, translating mathematical results into real-world understanding, and gaining appreciation for how models contribute to the development cycle of biomedical engineering applications. (Letter.) GE credit: SE. Effective: 2018 Spring Quarter.
BIM 118Microelectromechanical Systems (4) Active
Lecture—2 hour(s); Laboratory—3 hour(s); Discussion—1 hour(s). Prerequisite(s): CHE 002A; ENG 017. Pass One restricted to upper division standing in Biomedical Engineering. Introduction to the theory and practice of micro-electromechanical systems (MEMS), including fundamentals of micro-nanofabrication, microscale sensing and actuation, self assembly, microfluidics and lab-on-a-chip. Weekly hands-on laboratory sections are emphasized on implementation and utilization of MEMS technologies. (Letter.) GE credit: SE. Effective: 2017 Winter Quarter.
BIM 120Introduction to Materials Science for Biomedical Engineers (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 020 C- or better or ENG 105 C- or better; PHY 009C; MAT 022B recommended. Open to upper division BME students only. Historical perspective on materials usage in the body. Fundamental properties of materials and key considerations needed for material selection in the context of biomedical applications. Case studies of commonly used biomaterials spanning a range of material types. (Letter.) GE credit: SE. Effective: 2019 Winter Quarter.
BIM 125Introduction to Design and Analysis of Experiments for BME (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIM 105 or STA 100. Basic concepts and methods in design of experiments with biomedical engineering applications. Statistical concepts and methods to study strategies to design efficient industrial experiments that can improve data quality and simplify data analysis. (Letter.) GE credit: SE. Effective: 2018 Winter Quarter.
BIM 126Tissue Mechanics (3) Active
Lecture—2 hour(s); Laboratory—3 hour(s). Prerequisite(s): EXB 103 or ENG 045 or ENG 045Y. Structural and mechanical properties of biological tissues, including bone, cartilage, ligaments, tendons, nerves, and skeletal muscle. (Letter.) GE credit: SE. Effective: 2018 Spring Quarter.
BIM 140Protein Engineering (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIS 002A. Introduction to protein structure and function. Modern methods for designing, producing, and characterizing novel proteins and peptides. Design strategies, computer modeling, heterologous expression, in vitro mutagenesis. Protein crystallography, spectroscopic and calorimetric methods for characterization, and other techniques. (Letter.) GE credit: QL, SE, SL, VL. Effective: 2013 Fall Quarter.
BIM 140LProtein Engineering Laboratory (2) Active
Discussion—1 hour(s); Laboratory—3 hour(s). Prerequisite(s): BIM 140 (can be concurrent); Concurrent enrollment in BIM 140 required. Optional hands-on laboratory for BIM 140. Students use the engineering design process to design, build, and test a solution to a practical problem in the field of protein engineering. Problems change each offering. (Letter.) GE credit: SE. Effective: 2017 Spring Quarter.
BIM 141Cell and Tissue Mechanics (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): PHY 009B; ENG 006; ENG 035. Mechanical properties that govern blood flow in the microcirculation. Concepts in blood rheology and cell and tissue viscoelasticity, biophysical aspects of cell migration, adhesion, and motility. (Letter.) GE credit: QL, SE, VL. Effective: 2013 Fall Quarter.
BIM 142Principles and Practices of Biomedical Imaging (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 108 (can be concurrent); MAT 022B. Basic physics, engineering principles, and applications of biomedical imaging techniques including x-ray imaging, computed tomography, magnetic resonance imaging, ultrasound and nuclear imaging. (Letter.) GE credit: SE. Effective: 2018 Spring Quarter.
BIM 143Biomolecular Systems Engineering: Synthetic Biology (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIS 002A; (MAT 016C or MAT 017C or MAT 021C). Includes analysis, design, construction and characterization of molecular systems.  Process and biological parts standardization, computer aided design, gene synthesis, directed evolution, protein engineering, issues of human practice, biological safety, security, innovation, and ethics are covered. (Letter.) GE credit: SE. Effective: 2014 Fall Quarter.
BIM 143LSynthetic Biology Laboratory (2) Active
Discussion—1 hour(s); Laboratory—3 hour(s). Prerequisite(s): BIM 143 (can be concurrent); Concurrent enrollment in BIM 143 required. Optional hands-on laboratory for BIM 143. Students solve a practical problem in the field of synthetic biology by designing, building, and testing an appropriate solution or product. Problems change each offering. (Letter.) GE credit: SE. Effective: 2017 Spring Quarter.
BIM 144Fundamentals of Biophotonics and Bioimaging (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): MAT 022B; PHY 009B; or Consent of Instructor. BIM 108 or equivalent helpful; Biology or Physiology course recommended. Biophotonics and bioimaging, emphasizing quantitative description of light propagation & light tissue interactions. Key technologies and illustrative applications in basic research, clinical diagnostics and therapy. (Letter.) GE credit: SE. Effective: 2017 Winter Quarter.
BIM 145Immuno-Engineering (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 161A or BIS 102. Basic immunology and immunological tools. Survey of current immuno-therapeutic strategies. Ongoing research efforts to engineer the immune system for positive diagnostic and therapeutic outcomes. (Letter.) GE credit: SE. Effective: 2018 Fall Quarter.
BIM 151Mechanics of DNA (3) Active
Lecture—3 hour(s). Prerequisite(s): BIS 002A; MAT 022B. Structural, mechanical and dynamic properties of DNA. Topics include DNA structures and their mechanical properties, in vivo topological constraints on DNA, mechanical and thermodynamic equilibria, DNA dynamics, and their roles in normal and pathological biological processes. (Letter.) GE credit: OL, QL, SE. Effective: 2012 Fall Quarter.
BIM 152Molecular Control of Biosystems (4) Active
Lecture—3 hour(s); Lecture/Discussion—1 hour(s). Prerequisite(s): BIS 002A; PHY 009B; MAT 022B. Fundamentals of molecular biomedicine covering state-of-the-art methods for quantitative understanding of gene regulation and signal transduction networks at different levels of organization in health and disease. Topics include classic genetic systems, synthetic circuits, networks disrupted in disease and cancer. (Letter.) GE credit: OL, SE. Effective: 2012 Fall Quarter.
BIM 161ABiomolecular Engineering (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIS 002A; CHE 008B or CHE 118B. Restricted to upper division standing. Introduction to the basic concepts and techniques of biomolecular engineering such as recombinant DNA technology, protein engineering, and molecular diagnostics. Three units of credit for students who have taken BIM 161S. (Letter.) GE credit: QL, SE. Effective: 2017 Spring Quarter.
BIM 161LBiomolecular Engineering Laboratory (3) Active
Laboratory—4.5 hour(s); Lecture/Discussion—1.5 hour(s). Prerequisite(s): BIM 161A or BIS 101. Introduction to the basic techniques in biomolecular engineering. Lectures, laboratory, and discussion sessions will cover basic techniques in DNA cloning, bacterial cell culture, gene regulation, protein expression, and data analysis. (Letter.) GE credit: QL, SE, SL. Effective: 2013 Fall Quarter.
BIM 161SBiomolecular Engineering: Brief Course (1) Active
Lecture—1 hour(s). Prerequisite(s): BIS 002A; CHE 008B; BIM 161L (can be concurrent). Basic concepts and techniques in biomolecular analysis, recombinant DNA technology, and protein purification and analysis. Not open for credit to students who have taken BIM 161A. (Letter.) GE credit: QL, SE. Effective: 2012 Summer Session 2.
BIM 162Introduction to the Biophysics of Molecules and Cells (4) Active
Lecture—4 hour(s). Prerequisite(s): MAT 022B C- or better; PHY 009C C- or better. Introduction to fundamental physical mechanisms governing structure and function of bio-macromolecules. Emphasis on a quantitative understanding of the nano- to microscale biomechanics of interactions between and within individual molecules, as well as of their assemblies, in particular membranes. (Letter.) GE credit: QL, SE, SL. Effective: 2013 Fall Quarter.
BIM 163Bioelectricity, Biomechanics, and Signaling Systems (4) Active
Lecture—3 hour(s); Lecture/Discussion—1 hour(s). Prerequisite(s): MAT 022B C- or better; (BIM 116 or NPB 101). Fundamentals of bioelectricity in cells, the calcium signaling system, and mechanical force generation in muscle. Combination of lecture and projects to promote learning of important concepts in hands-on projects using neurons and muscle as microcosms. (Letter.) GE credit: QL, SE. Effective: 2014 Fall Quarter.
BIM 167Biomedical Fluid Mechanics (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIM 106 C- or better; NPB 101 or BIM 116. Theories of fluid mechanics, including Navier Stokes Equation and Conservation Laws, will be presented to understand dynamics of human circulatory systems. Fluid dynamics will be analyzed using partial differential equations. (Letter.) GE credit: SE. Effective: 2017 Spring Quarter.
BIM 170Aspects of Medical Device Design and Manufacturing (2) Active
Lecture—2 hour(s). Prerequisite(s): Consent of Instructor. Open to upper division Biomedical Engineering majors only. Survey of medical device design & impact on manufacturing operations. Introduction to medical device design process & product lifecycle. Principles of Design for Manufacturability, Design for Lean Manufacturing, and quality management systems. (Letter.) GE credit: SE. Effective: 2017 Winter Quarter.
BIM 171Clinical Applications for Biomedical Device Design (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): BIM 116 C- or better or NPB 101 C- or better; NPB 101 recommended. Restricted to Biomedical Engineering majors only. Clinical applications for biomedical devices with emphasis in the pathophysiology of common diseases as it relates to the biodesign process, biosensors principles, in vitro diagnostics, needs assessment, and regulatory considerations. (Letter.) GE credit: SE. Effective: 2017 Fall Quarter.
BIM 173Cell and Tissue Engineering (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 106 C- or better; BIM 109 C- or better. Engineering principles to direct cell and tissue behavior and formation. Cell sourcing, controlled delivery of macromolecules, transport within and around biomaterials, bioreactor design, tissue design criteria and outcomes assessment. (Letter.) GE credit: OL, SE, SL, WE. Effective: 2012 Fall Quarter.
BIM 174Microcontroller Applications Lab (2) Active
Laboratory—3 hour(s); Lecture—1 hour(s). Prerequisite(s): ENG 017 C- or better. Restricted to upper division BME students. Hands-on design module to introduce microcontroller platforms, e.g., Arduino; programming microcontroller development board, use of external programs to support development of controlled systems, design of simple control systems. No credit for students who have previously taken EEC 010. (Letter.) GE credit: SE. Effective: 2019 Winter Quarter.
BIM 176Microfluidic Lab (2) Active
Lecture—1 hour(s); Laboratory—3 hour(s). Prerequisite(s): CHE 002A; ENG 017. Upper division standing. Theory and practice of microfluidic and lab-on-a-chip (LOC) systems. Microfluidic theories, microfluidic functions and operations, microfluidic sensing, and organ-on-a-chip development. Laboratory sections emphasize implementation and utilization of modern microfluidic devices, interfacial phenomena, and digital and droplet microfluidics. (Letter.) GE credit: SE. Effective: 2019 Winter Quarter.
BIM 189ATopics in Biomedical Engineering; Cellular and Molecular Engineering (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Topics in Biomedical Engineering; Cellular and Molecular Engineering. May be repeated for credit topic differs. (Letter.) GE credit: SE. Effective: 2004 Fall Quarter.
BIM 189BTopics in Biomedical Engineering; Biomedical Imaging (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Topics in Biomedical Engineering; Biomedical Imaging. May be repeated for credit topic differs. (Letter.) GE credit: SE. Effective: 2004 Fall Quarter.
BIM 189CTopics in Biomedical Engineering; Biomedical Engineering (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Topics in Biomedical Engineering; Biomedical Engineering. May be repeated for credit topic differs. (Letter.) GE credit: SE. Effective: 2004 Fall Quarter.
BIM 190AUpper Division Seminar in Biomedical Engineering (1) Active
Seminar—1 hour(s). Restricted to upper division standing. In depth examination of research topics in a small group setting. Question and answer session with faculty members. May be repeated for credit. (P/NP grading only.) GE credit: SE. Effective: 2006 Spring Quarter.
BIM 192Internship in Biomedical Engineering (1-12) Active
Internship—3-36 hour(s). Prerequisite(s): Consent of Instructor. Restricted to upper division majors. Supervised work experience in the Biomedical Engineering field. May be repeated for credit. (P/NP grading only.) GE credit: SE. Effective: 2012 Fall Quarter.
BIM 198Directed Group Study (1-5) Active
Variable—3-15 hour(s). May be repeated up to 3 Time(s) content changes. (P/NP grading only.) GE credit: SE. Effective: 2005 Fall Quarter.
BIM 199Special Study for Advanced Undergraduates (1-5) Active
Variable—3-15 hour(s). Prerequisite(s): Consent of Instructor. Special study for advanced undergraduates. (P/NP grading only.) GE credit: SE. Effective: 2012 Fall Quarter.
BIM 201Scientific Communication for Biomedical Engineers (1) Active
Lecture/Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Course is designed to improve the written and oral communication skills of first-year graduate students through writing fellowship proposals, analyzing data, and critically reviewing research papers. (S/U grading only.) Effective: 2016 Fall Quarter.
BIM 202Cell and Molecular Biology for Engineers (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIS 104 or MCB 121. Preparation for research and critical review in the field of cell and molecular biology for biomedical or applied science engineers Emphasis on biophysical and engineering concepts intrinsic to specific topics including receptor-ligand dynamics in cell signaling and function, cell motility, DNA replication and RNA processing, cellular energetics and protein sorting. Modern topics in bioinformatics and proteomics. (Letter.) Effective: 2000 Fall Quarter.
BIM 204Physiology for Bioengineers (5) Active
Lecture—4 hour(s). Prerequisite(s): BIS 001A; Or equivalent; graduate standing or consent of instructor. Basic human physiology of the nervous, muscular, cardiovascular, respiratory, and renal systems and their interactions; Emphasis on the physical and engineering principles governing these systems, including control and transport processes, fluid dynamics, and electrochemistry. (Letter.) Effective: 2007 Fall Quarter.
BIM 209Scientific Integrity for Biomedical Engineers (2) Active
Lecture—1 hour(s); Discussion—1 hour(s). Open to Biomedical Engineering majors only. Scientific integrity and ethics for biomedical engineers, with emphasis and discussion on mentoring, authorship and peer review, use of humans and animals in biomedical research, conflict of interest, intellectual property, genetic technology and scientific record keeping. (S/U grading only.) Effective: 2006 Spring Quarter.
BIM 210Introduction to Biomaterials (4) Active
Lecture—4 hour(s). Prerequisite(s): ENG 045 or ENG 045Y; or Consent of Instructor. Mechanical and atomic properties of metallic,ceramic, and polymeric implant materials of metallic, ceramic, and polymeric implant materials; corrosion, degradation, and failure of implants;inflammation, wound and fracture healing, blood coagulation;properties of bones, joints, and blood vessels;biocompatibility of orthopaedic and cardiovascular materials. (Letter.) Effective: 2018 Spring Quarter.
BIM 211Design of Polymeric Biomaterials and Biological Interfaces (4) Active
Lecture—4 hour(s). Prerequisite(s): ENG 045 or ENG 045Y; or Consent of Instructor. Open to upper division undergraduates or graduate students. Design, selection and application of polymeric biomaterials. Integration of the principles of polymer science, surface science, materials science and biology. (Letter.) Effective: 2018 Spring Quarter.
BIM 212Biomedical Heat and Mass Transport Processes (4) Active
Lecture—3 hour(s); Discussion—1 hour(s). Prerequisite(s): EME 165; EBS 125; ECH 153; Or equivalent. Application of principles of heat and mass transfer to biomedical systems related to heat exchange between the biomedical system and its environment, mass transfer across cell membranes and the design and analysis of artificial human organs. (Same course as MAE 212.) (Letter.) Effective: 2000 Winter Quarter.
BIM 213Principles and Applications of Biological Sensors (4) Active
Lecture—4 hour(s). Prerequisite(s): CHE 002C. Biological sensors based on principles of electrochemical, optical and affinity detection. Methods for integration of sensing elements (e.g. enzymes) into biosensors and miniaturization of biosensors. (Letter.) Effective: 2007 Fall Quarter.
BIM 214Continuum Biomechanics (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 141; ENG 102; Or equivalent. Continuum mechanics relevant to bioengineering. Concepts in tensor calculus, kinematics, stress and strain, and constitutive theories of continua. Selected topics in bone, articular cartilage, blood/circulation, and cell biomechanics will illustrate the derivation of appropriate continuum mechanics theories. (Letter.) Effective: 2017 Fall Quarter.
BIM 216Advanced topics in Cellular Engineering (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 214; or Consent of Instructor. Advanced research strategies and technologies used in the study of immune function and inflammation. Static and dynamic measurements of stress, strain, and molecular scale forces in blood and vascular cells, as well as genetic approaches to the study of disease. (Letter.) Effective: 2000 Spring Quarter.
BIM 217Mechanobiology in Health and Disease (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 106; BIS 101; NPB 101; Or equivalents. Principles by which biomechanical forces affect cell and tissue function to impact human health and disease. Emphasis on cardiovascular system: structure and function, biofluid mechanics and mechanotransduction, disease mechanisms and research methods. Cartilage, bone and other systems; current topics discussed. (Letter.) Effective: 2008 Spring Quarter.
BIM 218Microsciences (4) Active
Lecture/Discussion—4 hour(s). Introduction to the theory of physical and chemical principles at the microscale. Scale effects, surface tension, microfluidic mechanics, micromechanical properties, intermolecular interactions and micro tribology. (Same course as EEC 244B.) (Letter.) Effective: 2011 Fall Quarter.
BIM 221Drug Delivery Systems (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 204 recommended but not required. Fundamental engineering and biotechnology principles critical for the formulation and delivery of therapeutic agents, including peptide/protein drugs and small molecules. (Letter.) Effective: 2017 Winter Quarter.
BIM 222Cytoskeletal Mechanics (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 202. Current topics in cytoskeletal mechanics including physical properties of the cytoskeleton and motor proteins, molecular force sensor and generator, cytoskeletal regulation of cell motility and adhesion. (Letter.) Effective: 2010 Fall Quarter.
BIM 223Multibody Dynamics (4) Active
Lecture—4 hour(s). Prerequisite(s): ENG 102. Coupled rigid-body kinematics/dynamics; reference frames; vector differentiation; configuration and motion constraints; holonomicity; generalized speeds; partial velocities; mass; inertia tensor/theorems; angular momentum; generalized forces; comparing Newton/Euler, Lagrange's, Kane's methods; computer-aided equation derivation; orientation; Euler; Rodrigues parameters. (Same course as MAE 223.) (Letter.) Effective: 2000 Winter Quarter.
BIM 225Spatial Kinematics and Robotics (4) Active
Lecture—3 hour(s); Laboratory—3 hour(s). Prerequisite(s): BIM 222; C Language. Spatial kinematics, screw theory, spatial mechanisms analysis and synthesis, robot kinematics and dynamics, robot workspace, path planning, robot programming, real-time architecture and software implementation. (Same course as MAE 225.) (Letter.) Effective: 2000 Winter Quarter.
BIM 228Skeletal Muscle Mechanics: Form, Function, Adaptability (4) Active
Lecture—4 hour(s). Prerequisite(s): ENG 035; (ENG 045 or ENG 045Y); MAT 021D; Basic background in biology, physiology, and engineering; NPB 101 recommended. Basic structure and function of skeletal muscle examined at the microscopic and macroscopic level. Muscle adaptation in response to aging, disease, injury, exercise, and disuse. Analytic models of muscle function are discussed. (Letter.) Effective: 2018 Spring Quarter.
BIM 232Skeletal Tissue Mechanics (3) Active
Lecture—3 hour(s); Laboratory—1 hour(s). Prerequisite(s): Engineering 104B. Overview of the mechanical properties of the various tissues in the musculoskeletal system, the relationship of these properties to anatomic and histologic structure, and the changes in these properties caused by aging and disuse. (Same course as MAE 232.) (Letter.) Effective: 1997 Winter Quarter.
BIM 233Soft Tissue Mechanics (4) Active
Lecture—4 hour(s). Presentation of structure and function of musculoskeletal soft tissues: cartilage, tendon, ligament, meniscus, and intervertebral disc. Instruction in engineering principals governing the mechanical behavior of these tissues: viscoelasticity, quasilinear viscoelasticity, and biphasic theory. (Letter.) Effective: 2013 Fall Quarter.
BIM 239Advanced Finite Elements and Optimization (4) Active
Lecture—4 hour(s). Prerequisite(s): ENG 180 or MAT 128C or EAD 115. Introduction to advanced finite elements and design optimization methods, with application to modeling of complex mechanical, aerospace and biomedical systems. Application of states of the art in finite elements in optimum design of components under realistic loading conditions and constraints. (Same course as EME 239.) (Letter.) Effective: 2007 Fall Quarter.
BIM 240Computational Methods in Nonlinear Mechanics (4) Active
Lecture—4 hour(s). Prerequisite(s): MAT 128B or ENG 180 or EAD 115. Deformation of solids and the motion of fluids treated with state-of-the-art computational methods. Numerical treatment of nonlinear dynamics; classification of coupled problems; applications of finite element methods to mechanical, aeronautical, and biological systems. (Same course as MAE 240.) (Letter.) Effective: 1999 Winter Quarter.
BIM 241Introduction to Magnetic Resonance Imaging (3) Active
Lecture—3 hour(s). Prerequisite(s): PHY 009D; MAT 022B. Equipment, methods, medical applications of MRI. Lectures review basic, advanced pulse sequences, image reconstruction, display and technology and how these are applied clinically. Lecture complements a more technical course. (course 246 can be taken concurrently.) (Letter.) Effective: 1999 Fall Quarter.
BIM 242Introduction to Biomedical Imaging (4) Active
Lecture—4 hour(s). Prerequisite(s): PHY 009D; Electrical and Computer Engineering 106 or consent of instructor. Basic physics and engineering principles of image science. Emphasis on ionizing and nonionizing radiation production and interactions with the body and detectors. Major imaging systems: radiography, computed tomography, magnetic resonance, ultrasound, and optical microscopy. (Letter.) Effective: 2004 Fall Quarter.
BIM 243Radiation Detectors for Biomedical Applications (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): PHY 009D; MAT 021D; MAT 022B. Radiation detectors and sensors used for biomedical applications. Emphasis on radiation interactions, detection, measurement and use of radiation sensors for imaging. Operating principles of gas, semiconductor, and scintillation detectors. (Letter.) Effective: 2005 Winter Quarter.
BIM 246Magnetic Resonance Technology (3) Active
Lecture—3 hour(s). Prerequisite(s): PHY 009D; MAT 022B. Course covers MRI technology at an advanced level with emphasis on mathematical descriptions and problem solving. Topics include spin dynamics, signal generation, image reconstruction, pulse sequences, biophysical basis of T1, T2, RF, gradient coil design, signal to noise, image artifacts. (Letter.) Effective: 1997 Winter Quarter.
BIM 251Medical Image Analysis (4) Active
Lecture—4 hour(s). Prerequisite(s): EEC 106. Techniques for assessing the performance of medical imaging systems. Principles of digital image formation and processing. Measurements that summarize diagnostic image quality and the performance of human observers viewing those images. Definition of ideal observer and other mathematical observers that may be used to predict performance from system design features. Students will obtain hands-on experience in computer vision by completing individual Matlab assignments that they select from topics in the course. (Letter.) Effective: 2001 Spring Quarter.
BIM 252Computational Methods in Biomedical Imaging (4) Active
Lecture—4 hour(s). Prerequisite(s): (BIM 105 or STA 120); (BIM 108 or EEC 150A). Analytic tomographic reconstruction from projections in 2D and 3D; model-based image reconstruction methods; maximum likelihood and Bayesian methods; applications to CT, PET, and SPECT. (Same course as EEC 205.) (Letter.) Effective: 2011 Fall Quarter.
BIM 254Statistical Methods in Genomics (4) Active
Lecture—4 hour(s). Statistical approaches to problems in computational molecular biology and genomics; formulation of questions via probabilistic modeling, statistical inference methods for parameter estimation, and interpretation of results to address biological questions; application to high-impact problems in functional genomics and molecular biology. (Letter.) Effective: 2017 Winter Quarter.
BIM 255Nanoscale Imaging for Molecular Medicine (3) Active
Lecture/Discussion—3 hour(s). Prerequisite(s): BIM 202 highly recommended; graduate standing. Current and emerging technologies to visualize biological structures and processes at size scales = 100 nanometers – and their application towards the advancement of molecular medicine. Technologies include superresolution optical microscopy, electron microscopy and tomography. Emphasis on quantitative imaging. (Same course as BPH 255.) (Letter.) Effective: 2017 Spring Quarter.
BIM 257Fundamentals of Tissue Optics and Biomedical Applications (5) Active
Lecture—3 hour(s); Discussion—1 hour(s); Laboratory—3 hour(s). Fundamentals of optical properties of tissue. Range of optical technologies and their applications to tissue characterization and diagnostics. (Letter.) Effective: 2011 Fall Quarter.
BIM 258Advanced Biophotonics and Bioimaging (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 108; PHY 108; Or an equivalent undergraduate optics course to PHY 108. Quantitative basis for biophotonics and bioimaging, with an emphasis on the physical and mathematical description of optics, light propagation, and light-tissue interactions. Advantages and limitations of various optical imaging and sensing technologies. Illustrative applications in diagnostics, basic research, and therapy. (Letter.) Effective: 2017 Winter Quarter.
BIM 262Cell and Molecular Biophysics for Bioengineers (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 284; Or equivalent; graduate standing; undergraduate students by consent of instructor. Introduction to fundamental mechanisms governing the structure, function, and assembly of bio-macromolecules. Emphasis is on a quantitative understanding of the nano-to-microscale interactions between and within individual molecules, as well as of their assemblies, in particular membranes. Not open for credit to students who have completed BIM 162. (Same course as ECH 269.) (Letter.) Effective: 2017 Winter Quarter.
BIM 263Optical Microscopy Hands-On (4) Active
Lecture/Discussion—2 hour(s); Laboratory—4 hour(s). Prerequisite(s): Consent of Instructor. Informed use of an optical research microscope. Analysis of digitized images. Optical image formation and its limitations. Laboratories on modern microscope usage and videomicroscopy techniques including optimization of recorded images and quantification of microscopic distances and displacements. (Letter.) Effective: 2018 Fall Quarter.
BIM 264Synthetic and Systems Engineering of Cells (4) Active
Lecture—4 hour(s). Introduction to the design, engineering, and control of biological systems for biotechnological applications and biological studies. (Letter.) Effective: 2016 Fall Quarter.
BIM 270Biochemical Systems Theory (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 202 (can be concurrent); or Consent of Instructor. Systems biology at the biochemical level. Mathematical and computational methods emphasizing nonlinear representation, dynamics, robustness, and optimization. Case studies of signal-transduction cascades, metabolic networks and regulatory mechanisms. Focus on formulating and answering fundamental questions concerning network function, design, and evolution.  (Letter.) Effective: 2004 Winter Quarter.
BIM 271Gene Circuit Theory (4) Active
Lecture—4 hour(s). Prerequisite(s): BIM 270 or BIM 202; and Consent of Instructor. Analysis, design, and construction of gene circuits. Modeling strategies, elements of design, and methods for studying variations in design. Case studies involving prokaryotic gene circuits to illustrate natural selection, discovery of design principles, and construction of circuits for engineering objectives. (Letter.) Effective: 2004 Winter Quarter.
BIM 272Tissue Engineering (3) Active
Lecture/Discussion—3 hour(s). Prerequisite(s): BIS 104 or MCB 121. Based on morphogenetic signals, responding stem cells and extracellular matrix scaffolding. Design and development of tissues for functional restoration of various organs damaged/lost due to cancer, disease and trauma. Fundamentals of morphogenetic signals, responding stem cells and extracellular matrix scaffolding. (Letter.) Effective: 2007 Winter Quarter.
BIM 273Integrative Tissue Engineering and Technologies (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 202; BIM 204; Or equivalent; strongly encourage completion of BIM 272 although not a prerequisite. Restricted to graduate standing. Engineering principles to direct cell and tissue behavior and formation. Contents include controlled delivery of macromolecules, transport within and around biomaterials, examination of mechanical forces of engineered constructs, and current experimental techniques used in the field. (Letter.) Effective: 2007 Spring Quarter.
BIM 281Acquisition and Analysis of Biomedical Signals (4) Active
Lecture—3 hour(s); Laboratory—3 hour(s). Prerequisite(s): ENG 100; STA 130A. Restricted to upper division engineering. Basic concepts of digital signal recording and analysis; sampling; empirical modeling; Fourier analysis, random processes, spectral analysis, and correlation applied to biomedical signals. (Letter.) Effective: 2002 Fall Quarter.
BIM 283Advanced Design of Experiments for Biomedical Engineers (4) Active
Lecture—4 hour(s). Open to graduate students only. Provides biomedical engineering graduate students with the tools to properly design experiments, collect and analyze data, and extract, communicate and act on information generated. Not open for credit to students who have taken EBS 265. (Letter.) Effective: 2017 Spring Quarter.
BIM 284Mathematical Methods for Biomedical Engineers (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): MAT 022B; STA 130A; Or consent of instructor; upper division biomedical engineering majors, and graduate students in sciences and engineering; priority given to Biomedical Engineering graduate students. Theoretical applications of linear systems, ordinary and partial differential equations, and probability theory and random processes that describe biological systems and instruments that measure them. Students will be introduced to numerical solution techniques in MATLAB. (Letter.) Effective: 2007 Fall Quarter.
BIM 286Nuclear Imaging in Medicine and Biology (4) Active
Lecture/Discussion—4 hour(s). Prerequisite(s): BIM 243; or Consent of Instructor. Radioactive decay, interaction of radiation with matter, radionuclide production, radiation detection, digital autoradiography, gamma camera imaging, single photon emission computed tomography, positron emission tomography and applications of these techniques in biology and medicine. (Letter.) Effective: 2005 Spring Quarter.
BIM 287Concepts in Molecular Imaging (4) Active
Lecture—2 hour(s); Lecture/Discussion—2 hour(s); Term Paper. Prerequisite(s): CHE 002C; MAT 021C; PHY 009D; and Consent of Instructor. Current techniques and tools for molecular imaging. Emphasis on learning to apply principles from the physical sciences to imaging problems in medicine and biology. (Letter.) Effective: 2004 Spring Quarter.
BIM 288Living Matter: Physical Biology of the Cell (3) Active
Lecture—3 hour(s). Open to any student possessing general background in any disciplines of physical or biological sciences and engineering. Introduction to the origin, maintenance, and regulation of the dynamic architecture of the cell, including cellular modes of organization, dynamics and energy dissipation, molecular transport, motility, regulation, and adaptability. (Same course as EMS 288 and BPH 288.) (Letter.) Effective: 2017 Winter Quarter.
BIM 289ASelected Topics in Biomedical Engineering; Cellular and Molecular Systems Engineering (1-5) Active
Variable—1-5 hour(s). Prerequisite(s): Consent of Instructor. Selected topics in Cellular and Molecular Systems Engineering. May be repeated for credit when topic differs. (Letter.) Effective: 2011 Fall Quarter.
BIM 289BSelected Topics in Biomedical Engineering; Biomedical Imaging (1-5) Active
Variable. Prerequisite(s): Consent of Instructor. Selected topics in Biomedical Imaging. May be repeated for credit when topic differs. (Letter.) Effective: 2011 Fall Quarter.
BIM 289CSelected Topics in Biomedical Engineering; Computational Bioengineering (1-5) Active
Variable. Prerequisite(s): Consent of Instructor. Selected topics in Computational Bioengineering. May be repeated for credit when topic differs. (Letter.) Effective: 2011 Fall Quarter.
BIM 289DSelected Topics in Biomedical Engineering; Cell and Tissue Biomechanics (1-5) Active
Variable. Prerequisite(s): Consent of Instructor. Selected topics in Cell and Tissue Biomechanics. May be repeated for credit when topic differs. (Letter.) Effective: 2011 Fall Quarter.
BIM 289ESelected Topics in Biomedical Engineering; Analysis of Human Movement (1-5) Active
Variable. Prerequisite(s): Consent of Instructor. Selected topics in Analysis of Human Movement. May be repeated for credit when topic differs. (Letter.) Effective: 2011 Fall Quarter.
BIM 290Seminar (1) Active
Seminar—1 hour(s). Seminar in biomedical engineering (S/U grading only.) Effective: 1997 Winter Quarter.
BIM 290CGraduate Research Conference (1) Active
Discussion—1 hour(s). Prerequisite(s): Consent of Instructor. Individual and/or group conference on problems, progress, and techniques in biomedical engineering research. May be repeated for credit. (S/U grading only.) Effective: 1997 Winter Quarter.
BIM 295Literature in Neuroengineering (2) Active
Seminar—2 hour(s). Open to graduate students only. Critical presentation and discussion of current literature in neuroengineering. May be repeated for credit. (Same course as NSC 295.) (S/U grading only.) Effective: 2018 Fall Quarter.
BIM 298Directed Group Study (1-5) Active
Variable—1-5 hour(s). Open to graduate students in the Biomedical Engineering Graduate Group, or consent of instructor. Directed group study in Biomedical Engineering. May be repeated for credit. (S/U grading only.) Effective: 2011 Fall Quarter.
BIM 299Research (1-12) Active
Variable. (S/U grading only.) Effective: 1997 Winter Quarter.
BIM 396Teaching Assistant Training Practicum (1-4) Active
Variable. Prerequisite(s): Graduate standing. May be repeated for credit. (P/NP grading only.) Effective: 1997 Winter Quarter.